Our body's inherent systems, particularly the liver and kidneys, play a critical role in the clearance of countless drugs. The function of these organs can be assessed using information on the clearance of test drugs (pharmacokinetic data) combined with computational models describing the absorption, distribution, metabolism and excretion (ADME) of these substances in the human body. This computational venture delves into these inner workings, focusing primarily on pharmacokinetics - the movement of drugs through the body. Interns will have the exciting opportunity to build a physiologically based model of drug elimination using existing literature data. This innovative model will be a powerful tool to simulate drug pharmacokinetics in silico, allowing hypotheses to be made about drug interactions, changes in metabolism due to disease or age, and more.
Why join us?
- Unique experience: Not every day you get to combine computational modelling with pharmaceutical science to influence the future of drug development.
- Real-world application: Use your model to answer real-world medical questions, such as drug interactions or variations in drug response across different demographics.
- No wet lab: While our project is deeply scientific, it's entirely computational. No wet lab work means you can fully immerse yourself in the world of digital modelling.
